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We intend to be a help community on premature ejaculation.
This website aimes to inform men suffering from premature ejaculation (PE) on treatment, cure and remedy to help overcome or stop PE. From the list of sexual dysfunctions this is the most common reported by men. Many myths and stories exists, but still little is openly discussed about this condition. For most men, this is not an illness, but a result of evolution, in which 'getting offspring' resulted in survival of the fittest. But as you can learn with the help of this site, for some men, this can be accuired, or the result of an illness.
This site is not run by a physician, nor is it the aim to replace medical experts. This is just a community providing some help. The information is open for reference, an extra way of learning about premature ejaculation.
Also a forum is newly offered, so experiences and questions can be shared. Feel free to post messages and discussions on premature ejaculation ( ejaculatio preacox ) and experiences with treatments, cures and medication.

Dapoxetine

A Novel Treatment Of Premature Ejaculation

In a recent study by Francisco Giuliano from Garches Frances studies the efficacy of a novel therapeutic agent, dapoxetine, for the treatment of premature ejaculation. The study is published in the July 2007 European Urology Supplements

In two-placebo controlled trials involving > 2600 men with PE dapoxetine 30 or 60 mg was given as needed 1-3 hours prior to sexual intercourse on an as needed basis was evaluated for the treatment of the condition. The mean age of the participant was 40 years. Lifelong PE was reported by 65% of the participants and 35% had PE that developed after a period of normal sexual function. The primary endpoint of the study was intravaginal ejaculatory latency time (IELT) as measured by stopwatch during intercourse. Analysis of the results showed a statistically significant dose-dependent increase in mean IELT and was observed during dapoxetine treatment at the study end point; 0.9 - 1.75 min, 0.92 - 2.78 min, and 0.91 - 3.32 minutes for placebo, dapoxetine 30 mg, and dapoxetine 60 mg. It was equally effective on the first dose and with subsequent doses and the improvement was sustained over the 12-week study period.

Dapoxetine was generally well tolerated with mild nausea and headache being the most common side effects. Nausea was reported in 8.7% of the 30 mg group and 20.1% of the 60 mg group. Headache was seen in 5.9% of the 30 mg group and 6.8% of the 60 mg group. Discontinuation rates due to adverse events for placebo, dapoxetine 30 mg and dapoxetine 60 mg were 0.9%, 4%, and 10%, respectively.

Reported by UroToday.com

See also Dapoxetine at prematureejaculation.sohosted.com on new medication

Health Canada warning

Health Canada is warning consumers not to use the unauthorized product Vigorect Oral Gel Shooter, because it contains an undeclared drug substance tadalafil, which should only be available by prescription. The use of Vigorect Oral Gel Shooter could pose serious health risks, especially for patients with existing medical conditions such as heart problems, those taking heart medication, or those at risk of stroke.

Products containing tadalafil should not be used by individuals who are taking any nitrate medication because combining these products could result in the development of potentially life-threatening low blood pressure.

Health Canada

RX-10100

A potential new drug for treatment of premature ejaculation is under tests.
Animal studies of RX-10100 demonstrate increases in dopamine and serotonin levels in the brain, making it not only a promising candidate for treating anxiety and depression but it may also be effective against sexual disorders such as erectile dysfunction and premature ejaculation. RX-10100 is expected to enter Phase II human clinical trials in 2007 for PE.
Source: http://www.rexahn.com

Tempe

Anesthetic spray may treat Premature Ejaculation. European researchers report on a topical anesthetic spray (TEMPE) that delays ejaculation by five times. The phase 2 study in the UK and the Netherlands included 54 heterosexual men with PE, ages 18 to 75. The men who received the TEMPE (Topical Eutectic Mixture for Premature Ejaculation) spray were able to delay ejaculation by just under an extra four minutes, while those in the placebo group delayed ejaculation by just over an extra 40 seconds. The findings are published in the February issue of the BJU International urology journal.
Desensitization as treatment for premature ejaculation
Article at Healthscout

Flomax

I received some references to Flomax which can cause ejaculation abnormalities. In this case, delayed ejaculation.

From 'Ejaculation by Ray Sahelian, M.D.'
Using Flomax (tamsulosin) every other day, rather than every day, appears to reduce the ejaculation problems that can occur with the drug. Given that the drug's effectiveness is not compromised with intermittent therapy, this dosing may become the standard for all men. Drugs such as Flomax are used to treat urinary symptoms related to an enlarged prostate -- a condition known as benign prostatic hyperplasia (BPH). Typical BPH symptoms include difficulty in starting to urinate, having a weak urinary flow, and the need to urinate urgently or frequently. However, Flomax can cause ejaculation abnormalities.

From Recent Progress in the Diagnosis and Treatment of Premature Ejaculation by Ira D. Sharlip, MD, and Gregory A. Broderick, MD
Gregory Broderick: I need to qualify that a little bit. Tamsulosin is notorious for causing what we believe to be retrograde ejaculation. Wayne Hellstrom from Tulane University has recently demonstrated that a significant percentage — maybe many as 30% or 40% of those men taking tamsulosin — will actually have anejaculation, a failure of emission. So we have long appreciated that men taking Flomax (tamsulosin) will come in with a climax complaint and that climax complaint is usually the absence of ejaculatory fluids or reduction in ejaculatory fluids. Wayne's recent study has demonstrated that anemission is occurring in a significant portion of them. But no — in my clinical experience, whether you are using Uroxatral (alfuzosin) or Flomax, I do not think that you actually see an improvement in PE. I do not think that they can be used to secondarily manage PE, and it remains controversial whether Uroxatral is actually better than Flomax in terms of preventing ejaculatory dysfunction such as failure of emission, but Wayne's recent study did suggest that was indeed the case.


http://www.raysahelian.com/ejaculation.html
http://x.medscape.com/viewprogram/4680


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